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1

Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies

Rob C. Roovers, Toon Laeremans, Lieven Huang, Severine De Taeye, Arie J. Verkleij, Hilde Revets, Hans J. de Haard, Paul M. P. van Bergen en Henegouwen

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 542 KB

english, 2007

2

On the Narrative Structure of Evgenij Onegin

Journal:

Russian Literature

Year:

1989

Language:

english

File:

PDF, 929 KB

english, 1989

3

Therapeutic bispecific antibody formats: a patent applications review (1994-2017)

Godar, Marie, de Haard, Hans, Blanchetot, Christophe, Rasser, Jacobus

Journal:

Expert Opinion on Therapeutic Patents

Year:

2018

Language:

english

File:

PDF, 2.30 MB

english, 2018

4

Reliable and controllable antibody fragment selections from Camelid non-immune libraries for target validation

Peter Verheesen, Andreas Roussis, Hans J. de Haard, Arjan J. Groot, Jord C. Stam, Johan T. den Dunnen, Rune R. Frants, Arie J. Verkleij, C. Theo Verrips, Silvère M. van der Maarel

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2006

Language:

english

File:

PDF, 911 KB

english, 2006

5

Properties, production, and applications of camelid single-domain antibody fragments

M. M. Harmsen, H. J. De Haard

Journal:

Applied Microbiology and Biotechnology

Year:

2007

Language:

english

File:

PDF, 243 KB

english, 2007

6

On Narration in Vojna i mir

Journal:

Russian Literature

Year:

1979

Language:

english

File:

PDF, 1.66 MB

english, 1979

7

Проза Юр. Юркуна между неосентиментализмом и эмоционализмом (Литературные отношения с М. Кузминым)

Journal:

Russian Literature

Year:

1999

File:

PDF, 1.58 MB

1999

8

Isolation of Llama Antibody Fragments for Prevention of Dandruff by Phage Display in Shampoo

Dolk, E., van der Vaart, M., Lutje Hulsik, D., Vriend, G., de Haard, H., Spinelli, S., Cambillau, C., Frenken, L., Verrips, T.

Journal:

Applied and Environmental Microbiology

Year:

2005

Language:

english

File:

PDF, 820 KB

english, 2005

9

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Liénart, Stéphanie, Merceron, Romain, Vanderaa, Christophe, Lambert, Fanny, Colau, Didier, Stockis, Julie, van der Woning, Bas, De Haard, Hans, Saunders, Michael, Coulie, Pierre G., Savvides, Savvas N

Journal:

Year:

2018

Language:

english

File:

PDF, 3.45 MB

english, 2018

10

Formatted anti–tumor necrosis factor α VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis

Ken Coppieters, Torsten Dreier, Karen Silence, Hans De Haard, Marc Lauwereys, Peter Casteels, Els Beirnaert, Heidi Jonckheere, Christophe Van De Wiele, Ludovicus Staelens, Jeroen Hostens, Hilde Revets

Journal:

Arthritis & Rheumatism

Year:

2006

Language:

english

File:

PDF, 361 KB

english, 2006

11

Lactobacillli expressing llama VHH fragments neutraliseLactococcusphages

Anna Hultberg, Denise M Tremblay, Hans de Haard, Theo Verrips, Sylvain Moineau, Lennart Hammarström, Harold Marcotte

Journal:

BMC Biotechnology

Year:

2007

Language:

english

File:

PDF, 705 KB

english, 2007

12

VHH selected against the viral spike protein can protect mice against lethal rabies virus challenge

Valérie Rosseels, Peter Vanlandschoot, Anna Hultberg, Theo Verrips, Michael Saunders, Hans de Haard, Aurélie Francart, Michael M Kalai, Steven Van Gucht

Journal:

BMC Proceedings

Year:

2011

Language:

english

File:

PDF, 137 KB

english, 2011

13

Characterization of anti-crystallin autoantibodies in patients with cataract

K. B. Merck, W. A. de Haard Hoekman, J. R. M. Cruysberg, H. Bloemendal, W. W. de Jong

Journal:

Molecular Biology Reports

Year:

1993

Language:

english

File:

PDF, 1.30 MB

english, 1993

14

Vitamin K1levels and K1-dependent coagulation factors II and X in preterm and small-for-date neonates

A. L. J. M. Pietersma-de Bruyn, P. J. C. van der Straaten, P. M. M. van Haard, J. C. Kuijpers, K. Hamulyák, J. H. Ruys

Journal:

European Journal of Pediatrics

Year:

1990

Language:

english

File:

PDF, 523 KB

english, 1990

15

Design of a Peptibody Consisting of the Antimicrobial Peptide dhvar5 and a llama Variable Heavy-chain Antibody Fragment

A. Szynol, J. J. W. De Haard, E. C. Veerman, J. J. De Soet, A. V. Van Nieuw Amerongen

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 174 KB

english, 2006

16

Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses

Spinelli, Silvia, Desmyter, Aline, Verrips, C Theo, de Haard, Hans J W, Moineau, Sylvain, Cambillau, Christian

Journal:

Nature Structural and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 539 KB

english, 2005

17

Determination of active single chain antibody concentrations in crude periplasmic fractions

Bert Kazemier, de Haard Hans, Piet Boender, Bob van Gemen, Hennie Hoogenboom

Journal:

Journal of Immunological Methods

Year:

1996

Language:

english

File:

PDF, 921 KB

english, 1996

18

Expression and aggregation of recombinant αA-crystallin and its two domains

Karin B. Merck, Willeke A. De Haard-Hoekman, Belinda B. Oude Essink, Hans Bloemendal, Wilfried W. De Jong

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1992

Language:

english

File:

PDF, 923 KB

english, 1992

19

Elastase inhibition by the C-terminal domains of α-crystallin and small heat-shock protein

Christina E.M. Voorter, Willeke de Haard-Hoekman, Karin B. Merck, Hans Bloemendal, Wilfried W. de Jong

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1994

Language:

english

File:

PDF, 457 KB

english, 1994

20

B.A. Uspenskij's Poètika kompozicii

Journal:

Russian Literature

Year:

1981

Language:

english

File:

PDF, 776 KB

english, 1981

21

Improved anti-IgG and HSA affinity ligands: Clinical application of VHH antibody technology

Rinse Klooster, Bram T.H. Maassen, Jord C. Stam, Pim W. Hermans, Mark R. ten Haaft, Frank J.M. Detmers, Hans J. de Haard, Jan A. Post, C. Theo Verrips

Journal:

Journal of Immunological Methods

Year:

2007

Language:

english

File:

PDF, 1.39 MB

english, 2007

22

Llama-derived phage display antibodies in the dissection of the human disease oculopharyngeal muscular dystrophy

S. van Koningsbruggen, H. de Haard, P. de Kievit, R.W. Dirks, A. van Remoortere, A.J. Groot, B.G.M. van Engelen, J.T. den Dunnen, C.T. Verrips, R.R. Frants, S.M. van der Maarel

Journal:

Journal of Immunological Methods

Year:

2003

Language:

english

File:

PDF, 745 KB

english, 2003

23

Creating and engineering human antibodies for immunotherapy

Hans de Haard, Paula Henderikx, Hennie R Hoogenboom

Journal:

Advanced Drug Delivery Reviews

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

24

Puškin's Translation of Moreau de Brasey's Memoirs

Journal:

Russian Literature

Year:

2003

Language:

english

File:

PDF, 1.26 MB

english, 2003

25

Поэзия в прозе Михаила Кузмина: стихотворные вставки

Journal:

Russian Literature

Year:

1997

File:

PDF, 1.75 MB

1997

26

Dissociation and Assembly of Pyridine Nucleotide Transhydrogenase from Azotobacter vinelandii

Gerrit VOORDOUW, Hans de HAARD, Johannus A. M. TIMMERMANS, Cees VEEGER, Pim ZABEL

Journal:

Year:

1982

Language:

english

File:

PDF, 1.08 MB

english, 1982

27

Studies on (Na+ + K+)-activated ATPase. XLVI. Effect of cation-induced conformational changes on sulfhydryl group modification

B.M. Schoot, S.E. Van Emst-De Vries, P.M.M. van Haard, J.J.H.H.M. de Pont, S.L. Bonting

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1980

Language:

english

File:

PDF, 672 KB

english, 1980

28

Vitamin K1 in the newborn

A.L.J.M.Pietersma-de Bruyn, P.M.M. van Haard

Journal:

Clinica Chimica Acta

Year:

1985

Language:

english

File:

PDF, 469 KB

english, 1985

29

Quantitation of trans-vitamin K1 in small serum samples by off-line multidimensional liquid chromatography

P.M.M.★van Haard, R. Engel, A.L.J.M. Pietersma-de★Bruyn

Journal:

Clinica Chimica Acta

Year:

1986

Language:

english

File:

PDF, 669 KB

english, 1986

30

Differential synthesis of crystallins in the developing rat eye lens

Christina E.M. Voorter, Willeke A. De Haard-Hoekman, Monique M.P. Hermans, Hans Bloemendal, Wilfried W. De Jong

Journal:

Experimental Eye Research

Year:

1990

Language:

english

File:

PDF, 3.40 MB

english, 1990

31

Protein engineering of α-crystallin

K.B. Merck, W.A. de Haard-Hoekman, H. Bloemendal, W.W. de Jong

Journal:

Experimental Eye Research

Year:

1992

Language:

english

File:

PDF, 127 KB

english, 1992

32

The in vivo phosphorylation sites of bovine αB-crystallin

Christina E.M. Voorter, Willeke A. de Haard-Hoekman, Eric S. Roersma, Helmut E. Meyer, Hans Bloemendal, Wilfried W. de Jong

Journal:

Year:

1989

Language:

english

File:

PDF, 354 KB

english, 1989

33

Alterations of sperm DNA integrity during cryopreservation procedure and in vitro incubation of bull semen

K.E. Waterhouse, A. Gjeldnes, A. Tverdal, P.M. De Angelis, W. Farstad, M. Håård, E. Kommisrud

Journal:

Animal Reproduction Science

Year:

2010

Language:

english

File:

PDF, 574 KB

english, 2010

34

Beneficial properties of single-domain antibody fragments for application in immunoaffinity purification and immuno-perfusion chromatography

P Verheesen, M.R ten Haaft, N Lindner, C.T Verrips, J.J.W de Haard

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2003

Language:

english

File:

PDF, 641 KB

english, 2003

35

Non-immunized natural human heavy chain CDR3 repertoires allow the isolation of high affinity peptides mimicking a human influenza hemagglutinin epitope

Sabrina Deroo, Aurélie Fischer, Nadia Beaupain, Manuel Counson, Nathalie Boutonnet, Jurgen Pletinckx, Stefan Loverix, Els Beirnaert, Hans De Haard, Jean-Claude Schmit, Ignace Lasters

Journal:

Molecular Immunology

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

36

G.P.7 05 Reliable and controllable antibody fragment selections from Camelid non-immune libraries

P. Verheesen, A. Roussis, Y. Huang, H. de Haard, A. de Groot, J.C. Stam, J.T. den Dunnen, R.R. Frants, A. Verkleij, C.T. Verrips, S.M. van der Maarel

Journal:

Neuromuscular Disorders

Year:

2006

Language:

english

File:

PDF, 43 KB

english, 2006

37

G.P.9 01 Prevention of oculopharyngeal muscular dystrophy-associated aggregation of nuclear poly(A)-binding protein with an intracellularly expressed camelid-derived antibody domain

P. Verheesen, A. de Kluijver, S. van Koningsbruggen, H. de Haard, G.J. van Ommen, C.T. Verrips, S.M. van der Maarel

Journal:

Neuromuscular Disorders

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

38

Preventing Phage Lysis of Lactococcus Lactis in Cheese Production Using A Neutralizing Heavy-Chain Antibody Fragment from Llama

A.M. Ledeboer, S. Bezemer, J.J.W. de Haard, I.M. Schaffers, C.T. Verrips, C. van Vliet, E.-M. Düsterhöft, P. Zoon, S. Moineau, L.G.J. Frenken

Journal:

Journal of Dairy Science

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

39

The influence of glucocorticoid on albumin synthesis and its messenger RNA in rat in vivo and in hepatocyte suspension culture

Han J. Moshage, Hans J.W. de Haard, Hans M.G. Princen, Sing Hiem Yap

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1985

Language:

english

File:

PDF, 547 KB

english, 1985

40

Targeting chemokines and chemokine receptors with antibodies

Alex Klarenbeek, David Maussang, Christophe Blanchetot, Michael Saunders, Sebastian van der Woning, Martine Smit, Hans de Haard, Erik Hofman

Journal:

Drug Discovery Today: Technologies

Year:

2012

Language:

english

File:

PDF, 224 KB

english, 2012

41

Vernier zone residue 4 of mouse subgroup II kappa light chains is a critical determinant for antigen recognition

de Haard, Hans, Kazemier, Bert, van der Bent, Arie, Oudshoorn, Peter, Boender, Piet, Arends, Jan-Willem, van Gemen, Bob

Journal:

Immunotechnology

Year:

1999

Language:

english

File:

PDF, 353 KB

english, 1999

42

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

Jahnichen, S., Blanchetot, C., Maussang, D., Gonzalez-Pajuelo, M., Chow, K. Y., Bosch, L., De Vrieze, S., Serruys, B., Ulrichts, H., Vandevelde, W., Saunders, M., De Haard, H. J., Schols, D., Leurs, R

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 345 KB

english, 2010

43

Broad and potent neutralization of HIV-1 by human-llama fusion antibodies derived from immunized llamas

McCoy, LE, Rutten, L, Dekkers, G, Blanchetot, C, Strokappe, NM, Forsman-Quigley, A, Seaman, MS, de Haard, H, Verrips, T, Weiss, RA

Journal:

Year:

2012

Language:

english

File:

PDF, 164 KB

english, 2012

44

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

Vandenbroucke, K, de Haard, H, Beirnaert, E, Dreier, T, Lauwereys, M, Huyck, L, Van Huysse, J, Demetter, P, Steidler, L, Remaut, E, Cuvelier, C, Rottiers, P

Journal:

Mucosal Immunology

Year:

2010

Language:

english

File:

PDF, 554 KB

english, 2010

45

Llama Antibody Fragments Have Good Potential for Application as HIV Type 1 Topical Microbicides

Gorlani, Andrea, Brouwers, Joachim, McConville, Christopher, van der Bijl, Pieter, Malcolm, Karl, Augustijns, Patrick, Quigley, Anna Forsman, Weiss, Robin, De Haard, Hans, Verrips, Theo

Journal:

AIDS Research and Human Retroviruses

Year:

2012

Language:

english

File:

PDF, 290 KB

english, 2012

46

Selection of Nanobodies that Target Human Neonatal Fc Receptor

Andersen, Jan Terje, Gonzalez-Pajuelo, Maria, Foss, Stian, Landsverk, Ole J. B., Pinto, Débora, Szyroki, Alexander, de Haard, Hans J., Saunders, Michael, Vanlandschoot, Peter, Sandlie, Inger

Journal:

Scientific Reports

Year:

2013

Language:

english

File:

PDF, 3.31 MB

english, 2013

47

P4-279

Van Dooren, Tom, Merchiers, P., Borghgraef, P., Dewachter, I., Van der Auwera, I., Wera, S., Lauwereys, M., Roland, B., Abulrob, A., Stanimirovic, D., Hoogenboom, H., de Haard, H., Van Leuven, F.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 70 KB

english, 2006

48

Voorzieningen in landelijke gegieden: een sociaal-geografisch onderzoek in Zuidwest-Friesland

Journal:

Journal of Rural Studies

Year:

1985

Language:

english

File:

PDF, 217 KB

english, 1985

49

Cloning and expression of the Lactococcus lactis subsp. Cremoris SK11 gene encoding an extracellular serine proteinase

de Vos, Willem M., Vos, Pieter, de Haard, Hans, Boerrigter, Ingrid

Journal:

Year:

1989

Language:

english

File:

PDF, 900 KB

english, 1989

50

Current Laboratory Techniques in Rabies Diagnosis, Research and Prevention || Generation of Immune Globulin Single Variable Domains by Display Technologies

Year:

2014

Language:

english

File:

PDF, 250 KB

english, 2014

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